Upcoming Journal Club Presentations (2):

Journal Club (15)

A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801

Patrick J Morris, Richard D Burke, Alok K Sharma, Daniel C Lynch, Leslie E Lemke-Boutcher, Shiny Mathew, Ikram Elayan, Deepa B Rao, Todd D Gould, Carlos A Zarate Jr, Panos Zanos, Ruin Moaddel, Craig J Thomas. 

Neurotoxicol Teratol. 2021 May 1;87:106993. doi: 10.1016/j.ntt.2021.106993. Epub ahead of print. PMID: 33945878.

Presenter: Patrick Morris, PhD, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Medical Center Drive Rockville, MD, USA

Journal Club (16)

Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial

Rebecca L Rothberg, Nour Azhari, Nancy A Haug, Elias Dakwar.

 J Psychopharmacol. 2021 Feb;35(2):150-158. doi: 10.1177/0269881120970879. Epub 2020 Dec 13. PMID: 33307947.

Presenter: Elias Dakwar, MD, Associate Professor of Clinical Psychiatry, New York State Psychiatric Institute, Columbia University Medical Center, New York, USA

Past Journal Club Presentations (14):

Translating the immediate effects of s-ketamine using hippocampal subfield analysis in healthy subjects-results of a randomized controlled trial

Anna Höflich, Christoph Kraus, Ruth M Pfeiffer, Rene Seiger, Dan Rujescu, Carlos A Zarate Jr, Siegfried Kasper, Dietmar Winkler, Rupert Lanzenberger.

Transl Psychiatry. 2021 Apr 1;11(1):200. doi: 10.1038/s41398-021-01318-6. PMID: 33795646.

Presenter: Anna Höflich, MD, PhD, (tenure track (EV) apl. Prof.), Medical University of Vienna, Department of Psychiatry and Psychotherapy, Neuroimaging Labs, Währinger Gürtel, Vienna, Austria

Effects of Ketamine on Rodent Fear Memory

Kwang H. Choi, Rina Y. Berman, Michael Zhang, Haley F. Spencer and Kennett D. Radford.

Int J Mol Sci. 2020 Sep 28;21(19):7173. doi: 10.3390/ijms21197173. PMID: 32998470.

Presenter: Kwang H. Choi, PhD, Assistant Professor of Psychiatry, Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University, Bethesda, MD, USA

Ketamine treatment upon memory retrieval reduces fear memory in marmoset monkeys

Philippens IHCHM, Draaisma L, Baarends G, Krugers HJ, Vermetten E. Ketamine treatment upon memory retrieval reduces fear memory in marmoset monkeys. Eur Neuropsychopharmacol. 2021 Apr 26;50:1-11. doi: 10.1016/j.euroneuro.2021.04.004. Epub ahead of print. PMID: 33915317.

Presenter: Ingrid Philippens, Senior Neuroscientist at the Animal science department at Biomedical Primate Research Centre (BPRC), The Hague, South Holland, Netherlands

Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain

Vogt KM, Ibinson JW, Smith CT, Citro AT, Norton CM, Karim HT, Popov V, Mahajan A, Aizenstein HJ, Reder LM, Fiez JA. 

Anesthesiology. 2021 Apr 19. doi: 10.1097/ALN.0000000000003774. Epub ahead of print. PMID: 33872345.

Presenter: Keith M. Vogt, MD, PhD, Assistant Professor, Anesthesiology & Perioperative Medicine @ University of Pittsburgh, Department of Anesthesiology, Pittsburgh, PA, USA

Distinct trajectories of antidepressant response to intravenous ketamine

O'Brien B, Lijffijt M, Lee J, Kim YS, Wells A, Murphy N, Ramakrishnan N, Swann AC, Mathew SJ. 

J Affect Disord. 2021 Mar 9;286:320-329. doi: 10.1016/j.jad.2021.03.006. Epub ahead of print. PMID: 33770540.
Presenter: Brittany O'Brien, Ph.D., Assistant Professor, Psychiatry and Behavioral Sciences Baylor College of Medicine Houston, TX, USA

Single, Fixed-Dose Intranasal Ketamine for Alleviation of Acute Suicidal Ideation. An Emergency Department, Trans-Diagnostic Approach: A Randomized, Double-Blind, Placebo- Controlled, Proof-of-Concept Trial

Domany Y, McCullumsmith CB. 

Arch Suicide Res. 2021 Feb 14:1-16. doi: 10.1080/13811118.2021.1878078. Epub ahead of print. PMID: 33583341
Presenter: Yoav Domany, MD, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA; Department of Psychiatry, Sheba Medical Center, Ramat Gan, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Tuesday 9th March 2021 | 12.30pm EST | 5.30pm UK

Ketamine Alters Electrophysiological Responses to Emotional Faces in Major Depressive Disorder

Lundin NB, Sepe-Forrest L, Gilbert JR, Carver FW, Furey ML, Zarate CA Jr, Nugent AC. 

J Affect Disord. 2021 Jan 15;279:239-249. doi: 10.1016/j.jad.2020.10.007. Epub 2020 Oct 7. PMID: 33074143

Presenter: Allison C Nugent, Ph.D., Director of the Magnetoencephalography (MEG) Core Facility, National Institute of Mental Health, Bethesda, MD, USA

Tuesday 23rd February 2021 | 12.30pm EST | 5.30pm UK

Comparative effects of (S)-ketamine and racemic (R/S)-ketamine on psychopathology, state of consciousness and neurocognitive performance in healthy volunteers

Torsten Passie, Hans-Anton Adams, Frank Logemann, Simon D Brandt, Birgitt Wiese, Matthias Karst. 

Eur Neuropsychopharmacol. 2021 Jan 21;S0924-977X(21)00007-9 .PMID: 33487513

Presenter: Torsten Passie M.D., Ph.D., Professor of Psychiatry and Psychotherapy Goethe-University Franfurt/Main, Germany; (Visiting Scientist) Hannover Medical School, Germany (affiliate)

Tuesday 9th February 2021 12.30pm EST; 5.30pm UK

Prolonged ketamine infusion modulates limbic connectivity and induces sustained remission of treatment-resistant depression. 

Siegel JS, Palanca BJA, Ances BM, Kharasch ED, Schweiger JA, Yingling MD, Snyder AZ, Nicol GE, Lenze EJ, Farber NB.  

Psychopharmacology (Berl). 2021 Jan 22. PMID: 33483802.

Presenter: Josh Siegel, MD, PhD, Psychiatry Resident, Washington University St Louis, USA

Tuesday 12th January 2021 12.30pm EST; 5.30pm UK

An RCT of repeated ketamine administration for chronic post-traumatic stress disorder

Feder A, Costi S, Rutter SB, Collins AB, Govindarajulu U, Jha MK, Horn SR, Kautz M, Corniquel M, Collins KA, Bevilacqua L, Glasgow AM, Brallier J, Pietrzak RH, Murrough JW, Charney DS.  

Am J Psychiatry. 2021 Jan 5: doi: 10.1176/appi.ajp.2020.20050596. Epub ahead of print. PMID: 33397139

Presenter: Adriana Feder, Associate Professor, Icahn School of Medicine, Mount Sinai, New York 

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